As you might imagine, Night of Champions has traditionally been the setting for many new champions being crowned.
In fact, last year's show was the first in its history where only one belt changed hands. With three titles being won earlier this month at SummerSlam, it's probable that we'll see some new champions begin their reign with a successful defence, but it would be very surprising to see the night go by without at least one title being lost and won.
The most likely candidate to lose their title is the United States champion,
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